An increase in circulating amino acid levels overloads functioning of kidneys by increasing glomerular filtration rate, an indicator of kidney function in humans. Hence a sustained intake of excess dietary protein likely accelerates the progression of kidney failure. In addition, elevated blood amino acid levels induce insulin resistance, leading to metabolic abnormalities in humans. Therefore, we focused on inhibiting gut amino acid intake into the circulation to improve kidney function and metabolic disease.

Enteropeptidase is a gut-localized pivotal enzyme that activates protein digestion events in mammals. We identified SCO-792, an orally available enteropeptidase inhibitor with first-in-class potential, that can inhibit gut amino acid intake into the circulation. SCO-792 treatment improves kidney and metabolic parameters in preclinical models of diabetic kidney disease (DKD) and chronic kidney disease.

In a phase 2 proof-of-concept study, 12-week treatment with SCO-792 resulted in a clinically significant reduction in the urine albumin-to-creatinine ratio from baseline in patients with DKD. In addition, SCO-792 treatment was associated with decreased HbA1c and fasting glucose levels.

SCOHIA is actively seeking partnerships worldwide for the development and commercialization of SCO-792 (Contact here for partnering).

Indication ：

  • Diabetic kidney disease
  • Chronic kidney disease
  • Diabetes

Clinical Trial Information

  • SCOHIA initiates a phase 2 proof of concept study on an enteropeptidase inhibitor (SCO-792) for diabetic kidney disease

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  • SCOHIA initiates a phase 2 proof of concept study of an enteropeptidase inhibitor (SCO-792) in obese patients with type 2 diabetes mellitus

    Link

Scientific Publication

  • Publication of a clinical phase 2 study of SCO-792

    Link

  • Publication of medicinal chemistry research on SCO-792, an enteropeptidase inhibitor

    Link

  • Publication of a preclinical study: the enteropeptidase inhibitor SCO-792 is therapeutically effective for improving renal function in a nondiabetic rat model of chronic kidney disease

    Link

  • Publication of a preclinical study: SCO-792, an enteropeptidase inhibitor, improves obesity via microbiota-driven mechanisms in mice

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  • Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease

    ・Diabetes, Obesity and Metabolism

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  • SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice.

    ・Diabetes, Obesity and Metabolism

    Link

  • Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.

    ・Pharmacology Research & Perspectives

    Link
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