SCO-792 is an oral inhibitor of enteropeptidase, which is localized in the duodenum and controls the digestion of proteins in the gastrointestinal tract. Administration of this drug has shown dramatic improvement of obesity and metabolism in preclinical studies and is considered to partially mimic bariatric surgery. The Phase 1 clinical study has been completed and the Phase 2 clinical study is currently being prepared.

Indication

  • Obesity
  • Diabetes
  • Diabetic kidney disease
  • Change
  • Activation
  • Benefits
  • Inhibition
  • Food passage
  • Protein

Obese patients

Trypsinogen
Trypsin

Excessive protein

Blood glucose
level

Body weight

ENTP

SCO-792 administration

SCO-792
ENTP

Peripheral protein

Blood glucose
level

Body weight

Bariatric surgery

Gastric
resection
ENTP

Peripheral protein

Blood glucose
level

Body weight

ENTP : Enteropeptidase

In obese and diabetic patients, increased protein intake results in higher absorption of amino acids in the gastrointestinal tract, leading to altered metabolism and weight regulation. By inhibiting enteropeptidase localized in the duodenum, SCO-792 suppresses protein degradation, controlling the absorption of amino acid and increasing the absorption of undigested protein in the gastrointestinal tract. In bariatric surgery, which is known to be effective in patients with diabetes and obesity, changes in proteins and amino acids are similar to those induced by inhibition of enteropeptidase. That is, SCO-792 shows its efficacy by partially mimicking the surgery.