SCO-267 is an oral agonist of GPR40, a G-protein-coupled receptor expressed in the islet and gastrointestinal tract. SCO-267 promotes secretion of pancreatic and gastrointestinal hormones and has been confirmed to improve metabolism and reduce body weight. Preclinical studies confirmed favorable safety, and preparations are being made for a Phase 1 clinical study.

Indication

  • Obesity
  • Diabetes
  • Activation
  • Benefits
SCO-267
GPR40

Pancreas

Pancreas

Insulin secretion

Glucagon secretion

Intestine

Intestine

GLP-1
secretion

PYY
secretion

GIP
secretion

Blood glucose level

Body weight

GLP-1 : Glucagon-like peptide 1

PYY : Peptide YY

GIP : Glucose-dependent insulinotropic peptide

SCO-267 acts on a fatty acid receptor GPR40. Activation of GPR40 shows the powerful effect of lowering blood glucose and reducing body weight by stimulating secretion of insulin mainly in the pancreas and gastrointestinal hormones in the gastrointestinal tract. In preclinical studies, SCO-267 has been confirmed to be effective in improving metabolism and reducing body weight as a result of an increased secretion of pancreatic hormones such as insulin and glucagon and gastrointestinal hormones like GLP-1, GIP and PYY.